<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:7bbed507-8673-4b66-ab45-07e4915e856b,g:0785a775-d7f9-4ff1-bae1-b6a1e9f0ea94-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.upstartholdings.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="upst-20220630.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_0c1c5a22-269b-496b-b0b0-69b45f0db5a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_9b83b7a9-d30c-437a-b148-9eee6ba496d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0c1c5a22-269b-496b-b0b0-69b45f0db5a5" xlink:to="loc_us-gaap_CommonStockValue_9b83b7a9-d30c-437a-b148-9eee6ba496d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_199eab4d-6c6c-4d8a-b9f7-4f0b4744a88a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0c1c5a22-269b-496b-b0b0-69b45f0db5a5" xlink:to="loc_us-gaap_AdditionalPaidInCapital_199eab4d-6c6c-4d8a-b9f7-4f0b4744a88a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_e37360dd-3c80-4245-90de-30418328ff6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_0c1c5a22-269b-496b-b0b0-69b45f0db5a5" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_e37360dd-3c80-4245-90de-30418328ff6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_8fb794aa-9870-4804-a344-bf72eaa7c8e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_RestrictedCash_8fb794aa-9870-4804-a344-bf72eaa7c8e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_90e4d4ab-80fa-414d-aea8-0ea6b76186c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_90e4d4ab-80fa-414d-aea8-0ea6b76186c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_ba12a9c4-4d17-40ff-aef9-873710dd64fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_ba12a9c4-4d17-40ff-aef9-873710dd64fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableNet_a3fe872c-207b-4a03-8a97-a69661e1fc19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_NotesReceivableNet_a3fe872c-207b-4a03-8a97-a69661e1fc19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_66da8deb-189c-40d0-aa66-4b5b3e04d92e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_66da8deb-189c-40d0-aa66-4b5b3e04d92e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_22ede756-dbb9-446e-a804-27caf57405af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_22ede756-dbb9-446e-a804-27caf57405af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_68992fc2-ca11-4981-a3e4-4ce9c5eec0f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_Goodwill_68992fc2-ca11-4981-a3e4-4ce9c5eec0f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_5b0fb41e-e0dd-468c-8e41-322b86e69b21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_OtherAssets_5b0fb41e-e0dd-468c-8e41-322b86e69b21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Cash_5e155053-3d91-4c46-9091-8371c9cd4f96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Cash"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a9ab4e3c-1f47-4f60-93f7-fc84a06fb80f" xlink:to="loc_us-gaap_Cash_5e155053-3d91-4c46-9091-8371c9cd4f96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_2a43fcf6-1dab-42f2-99ed-cae1528cd475" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrentAndNoncurrent_0dc14fd7-0c48-4cae-9205-971cd9df7b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_2a43fcf6-1dab-42f2-99ed-cae1528cd475" xlink:to="loc_us-gaap_AccountsPayableCurrentAndNoncurrent_0dc14fd7-0c48-4cae-9205-971cd9df7b2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_PayableToInvestors_4064e7e6-af6e-4d2b-8c48-19bb215bc508" xlink:href="upst-20220630.xsd#upst_PayableToInvestors"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_2a43fcf6-1dab-42f2-99ed-cae1528cd475" xlink:to="loc_upst_PayableToInvestors_4064e7e6-af6e-4d2b-8c48-19bb215bc508" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_eacfefaa-63a5-450a-8f45-cb2e51d894f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_2a43fcf6-1dab-42f2-99ed-cae1528cd475" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_eacfefaa-63a5-450a-8f45-cb2e51d894f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_1449b15a-0370-4fe7-a0ad-8ce2e2f30245" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_2a43fcf6-1dab-42f2-99ed-cae1528cd475" xlink:to="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_1449b15a-0370-4fe7-a0ad-8ce2e2f30245" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_378a5dba-d751-4b48-bb23-62513ff2fb49" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_2a43fcf6-1dab-42f2-99ed-cae1528cd475" xlink:to="loc_us-gaap_OperatingLeaseLiability_378a5dba-d751-4b48-bb23-62513ff2fb49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_9a686bec-43e6-43b6-ad5e-273b18ce70f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_fa6b72b7-768a-4f92-a21a-0940a1a833e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_9a686bec-43e6-43b6-ad5e-273b18ce70f5" xlink:to="loc_us-gaap_Liabilities_fa6b72b7-768a-4f92-a21a-0940a1a833e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_5596e772-50e1-4aa9-bda2-af4b2a533057" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_9a686bec-43e6-43b6-ad5e-273b18ce70f5" xlink:to="loc_us-gaap_StockholdersEquity_5596e772-50e1-4aa9-bda2-af4b2a533057" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveIncomeLoss" xlink:type="simple" xlink:href="upst-20220630.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveIncomeLoss"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_532b3663-152a-4762-a52f-87b9dd39f4ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_4e9fe142-38c8-4130-aed9-85092c682559" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_532b3663-152a-4762-a52f-87b9dd39f4ea" xlink:to="loc_us-gaap_SellingAndMarketingExpense_4e9fe142-38c8-4130-aed9-85092c682559" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_CustomerOperationsExpense_c837f015-477d-4cc8-9b3e-6f51693e5e9f" xlink:href="upst-20220630.xsd#upst_CustomerOperationsExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_532b3663-152a-4762-a52f-87b9dd39f4ea" xlink:to="loc_upst_CustomerOperationsExpense_c837f015-477d-4cc8-9b3e-6f51693e5e9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_bce28bde-406a-4a58-924e-8809a60913b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_532b3663-152a-4762-a52f-87b9dd39f4ea" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_bce28bde-406a-4a58-924e-8809a60913b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_49d7c68b-c42e-47c5-a797-bf36a2dcb1fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_532b3663-152a-4762-a52f-87b9dd39f4ea" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_49d7c68b-c42e-47c5-a797-bf36a2dcb1fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_7046f2a8-c35b-4222-87d4-bb8f25fa6079" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_77b8effa-5cb2-476e-92fd-ea422daa942b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_7046f2a8-c35b-4222-87d4-bb8f25fa6079" xlink:to="loc_us-gaap_Revenues_77b8effa-5cb2-476e-92fd-ea422daa942b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_9dfa87cf-7607-48c0-9021-807bceb00f8e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_7046f2a8-c35b-4222-87d4-bb8f25fa6079" xlink:to="loc_us-gaap_OperatingExpenses_9dfa87cf-7607-48c0-9021-807bceb00f8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_c796f9fc-dbd6-4332-845a-6d5b11ec6f71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3d8963d5-e2f9-437d-9e4e-393610bb133a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_c796f9fc-dbd6-4332-845a-6d5b11ec6f71" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3d8963d5-e2f9-437d-9e4e-393610bb133a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_d284ab58-c696-49a2-bec4-7b948aab9961" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_c796f9fc-dbd6-4332-845a-6d5b11ec6f71" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_d284ab58-c696-49a2-bec4-7b948aab9961" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f3c93822-dd9e-4830-8758-060a5db063bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_453dbc77-cf35-40fa-b479-9b7061356a2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_f3c93822-dd9e-4830-8758-060a5db063bc" xlink:to="loc_us-gaap_IncomeLossAttributableToParent_453dbc77-cf35-40fa-b479-9b7061356a2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_15e4072e-9d30-46da-b2a7-d5e1c0696b5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_f3c93822-dd9e-4830-8758-060a5db063bc" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_15e4072e-9d30-46da-b2a7-d5e1c0696b5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_24246514-e41f-4328-bea0-5fbf7b1b4805" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_d170300f-3b8c-4dc2-ba0a-ebc1933b1a29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_24246514-e41f-4328-bea0-5fbf7b1b4805" xlink:to="loc_us-gaap_OperatingIncomeLoss_d170300f-3b8c-4dc2-ba0a-ebc1933b1a29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_4c1f199a-645c-4ce0-a563-0832170bc645" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_24246514-e41f-4328-bea0-5fbf7b1b4805" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_4c1f199a-645c-4ce0-a563-0832170bc645" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="upst-20220630.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_729d7c55-acae-4deb-8b1e-d582877bfa67" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_674cb4af-744e-45b3-9050-7b17f3fc3217" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_729d7c55-acae-4deb-8b1e-d582877bfa67" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_674cb4af-744e-45b3-9050-7b17f3fc3217" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edad8926-1856-4920-8690-39cd0c792bf1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_729d7c55-acae-4deb-8b1e-d582877bfa67" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_edad8926-1856-4920-8690-39cd0c792bf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_c80c715a-efe0-4661-a301-e1b0ba9cb859" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_729d7c55-acae-4deb-8b1e-d582877bfa67" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_c80c715a-efe0-4661-a301-e1b0ba9cb859" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_048c31aa-1938-4203-852b-9401d51550f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_2b335743-44ff-4293-95af-07fb325191a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_048c31aa-1938-4203-852b-9401d51550f8" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_2b335743-44ff-4293-95af-07fb325191a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_416e7b63-4db2-4d26-a441-db1d2dd559df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_048c31aa-1938-4203-852b-9401d51550f8" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_416e7b63-4db2-4d26-a441-db1d2dd559df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_7a6b6a29-2c19-46b2-8827-62ea2f4c7be8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_048c31aa-1938-4203-852b-9401d51550f8" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_7a6b6a29-2c19-46b2-8827-62ea2f4c7be8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_3e85d5cf-d73c-49c6-8ab7-1aa501b6a85d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_048c31aa-1938-4203-852b-9401d51550f8" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_3e85d5cf-d73c-49c6-8ab7-1aa501b6a85d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_52f63f46-c6d1-4af1-9660-0dd5ff70acf2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_048c31aa-1938-4203-852b-9401d51550f8" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_52f63f46-c6d1-4af1-9660-0dd5ff70acf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_aee63376-be04-473c-8d45-0e7f79533346" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_048c31aa-1938-4203-852b-9401d51550f8" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_aee63376-be04-473c-8d45-0e7f79533346" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_a9cba324-a507-4cfe-89db-befdc60e7e97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_048c31aa-1938-4203-852b-9401d51550f8" xlink:to="loc_us-gaap_RepaymentsOfDebt_a9cba324-a507-4cfe-89db-befdc60e7e97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_0bb892fa-76ce-4f32-bc30-f0dfd94b78dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_0bb892fa-76ce-4f32-bc30-f0dfd94b78dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_0c337c3a-0e08-4dc4-ae6e-02bd2743394d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_0c337c3a-0e08-4dc4-ae6e-02bd2743394d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_825645d1-ba19-4477-8e95-4ba12396c5d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_NetIncomeLoss_825645d1-ba19-4477-8e95-4ba12396c5d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_14a9e331-94b8-4b46-a26d-8edb653e2227" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_14a9e331-94b8-4b46-a26d-8edb653e2227" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_3fa108e6-aa21-404b-b57a-54f3d01f557b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_ShareBasedCompensation_3fa108e6-aa21-404b-b57a-54f3d01f557b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfLoansHeldForSale_764409d9-d959-4087-8f36-2eacc058ffec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleOfLoansHeldForSale"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_ProceedsFromSaleOfLoansHeldForSale_764409d9-d959-4087-8f36-2eacc058ffec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInFinancialInstrumentsUsedInOperatingActivities_0d67b9fd-f553-43d3-8af8-be724c52c2e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInFinancialInstrumentsUsedInOperatingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_IncreaseDecreaseInFinancialInstrumentsUsedInOperatingActivities_0d67b9fd-f553-43d3-8af8-be724c52c2e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_IncreaseDecreaseInOperatingLeaseLiabilityAndRightOfUseAsset_c08968e7-7137-4dc4-bf2c-c2a6fc9c15ad" xlink:href="upst-20220630.xsd#upst_IncreaseDecreaseInOperatingLeaseLiabilityAndRightOfUseAsset"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_upst_IncreaseDecreaseInOperatingLeaseLiabilityAndRightOfUseAsset_c08968e7-7137-4dc4-bf2c-c2a6fc9c15ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfLoansHeldForSale_d8083a31-86dd-44e3-8c83-9caf403199bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromCollectionOfLoansHeldForSale"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_ProceedsFromCollectionOfLoansHeldForSale_d8083a31-86dd-44e3-8c83-9caf403199bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_GainLossOnLoanServicingArrangementsAndSaleOfNoncontrollingInterestsNet_4254a0d2-ec08-405b-9bd6-4042cf53adb9" xlink:href="upst-20220630.xsd#upst_GainLossOnLoanServicingArrangementsAndSaleOfNoncontrollingInterestsNet"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_upst_GainLossOnLoanServicingArrangementsAndSaleOfNoncontrollingInterestsNet_4254a0d2-ec08-405b-9bd6-4042cf53adb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToPurchaseLoansHeldForSale_6f6d2b6c-54c5-4424-8dd0-3533fb716c93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToPurchaseLoansHeldForSale"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_PaymentsToPurchaseLoansHeldForSale_6f6d2b6c-54c5-4424-8dd0-3533fb716c93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_IncreaseDecreaseInPayableToInvestors_82844cec-b495-44f1-85f2-143f5c042e4b" xlink:href="upst-20220630.xsd#upst_IncreaseDecreaseInPayableToInvestors"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_upst_IncreaseDecreaseInPayableToInvestors_82844cec-b495-44f1-85f2-143f5c042e4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_9613660b-19bd-4ee4-b362-a2dbd7ff6aa0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayableTrade"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_9613660b-19bd-4ee4-b362-a2dbd7ff6aa0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_4a7e998c-155a-4362-ae45-84ef8c848ae7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_4a7e998c-155a-4362-ae45-84ef8c848ae7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_PurchaseOfLoansForImmediateResale_5c5afaa0-41c1-4b56-b790-7d4065d7ca6f" xlink:href="upst-20220630.xsd#upst_PurchaseOfLoansForImmediateResale"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_upst_PurchaseOfLoansForImmediateResale_5c5afaa0-41c1-4b56-b790-7d4065d7ca6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_ProceedsFromImmediateResaleOfLoans_ca9a077a-4ca9-4509-9ae2-8cf35478cb51" xlink:href="upst-20220630.xsd#upst_ProceedsFromImmediateResaleOfLoans"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8c13abe7-aeba-446c-b1ce-726c77e9c110" xlink:to="loc_upst_ProceedsFromImmediateResaleOfLoans_ca9a077a-4ca9-4509-9ae2-8cf35478cb51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_e768a129-354c-47e8-baa3-e9da14a565b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Cash_a1e2f155-6b97-4d87-b802-c03958445e05" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Cash"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_e768a129-354c-47e8-baa3-e9da14a565b4" xlink:to="loc_us-gaap_Cash_a1e2f155-6b97-4d87-b802-c03958445e05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_79ed5349-2b86-4683-94b9-08d3347969e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_e768a129-354c-47e8-baa3-e9da14a565b4" xlink:to="loc_us-gaap_RestrictedCash_79ed5349-2b86-4683-94b9-08d3347969e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForSoftware_758f85ce-09d0-4608-86e9-675b622fab6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForSoftware"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:to="loc_us-gaap_PaymentsForSoftware_758f85ce-09d0-4608-86e9-675b622fab6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_b4541710-a9ba-44a0-bd0a-92f59603a9b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_b4541710-a9ba-44a0-bd0a-92f59603a9b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_cd5df08d-effc-4c6c-9e27-0452500ffe75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:to="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_cd5df08d-effc-4c6c-9e27-0452500ffe75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_4b6a23b8-f5f5-4a72-a9e2-d6b23f7bf201" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_4b6a23b8-f5f5-4a72-a9e2-d6b23f7bf201" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLoansHeldForInvestment_5e1bd5bc-c108-4df3-b70b-63f02d1167f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireLoansHeldForInvestment"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:to="loc_us-gaap_PaymentsToAcquireLoansHeldForInvestment_5e1bd5bc-c108-4df3-b70b-63f02d1167f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfLoansHeldForInvestment_89959bb9-d288-4f9c-be4a-a81d791b7076" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleOfLoansHeldForInvestment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:to="loc_us-gaap_ProceedsFromSaleOfLoansHeldForInvestment_89959bb9-d288-4f9c-be4a-a81d791b7076" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPrincipalRepaymentsOnLoansAndLeasesHeldForInvestment_0684f2b8-d766-4c78-82f7-94ad026cd137" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromPrincipalRepaymentsOnLoansAndLeasesHeldForInvestment"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:to="loc_us-gaap_ProceedsFromPrincipalRepaymentsOnLoansAndLeasesHeldForInvestment_0684f2b8-d766-4c78-82f7-94ad026cd137" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_e74842d2-573d-4810-8f16-7ce15705356d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireOtherInvestments"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b4a116d0-1eb7-4f26-a695-9850a19c0695" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_e74842d2-573d-4810-8f16-7ce15705356d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/RevenueInterestIncomeandFairValueAdjustmentsDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#RevenueInterestIncomeandFairValueAdjustmentsDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/RevenueInterestIncomeandFairValueAdjustmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_upst_InterestIncomeAndFairValueAdjustmentNet_962ad429-9d97-451d-b4bc-16ce428c7c5c" xlink:href="upst-20220630.xsd#upst_InterestIncomeAndFairValueAdjustmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_fbf1348f-05a3-47e4-b28d-c485be24a674" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_InterestIncomeAndFairValueAdjustmentNet_962ad429-9d97-451d-b4bc-16ce428c7c5c" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_fbf1348f-05a3-47e4-b28d-c485be24a674" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_8a8295bc-0cf3-453f-bdbe-2083c7ccc80f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_InterestIncomeAndFairValueAdjustmentNet_962ad429-9d97-451d-b4bc-16ce428c7c5c" xlink:to="loc_us-gaap_InterestExpense_8a8295bc-0cf3-453f-bdbe-2083c7ccc80f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_FairValueAndOtherAdjustmentsNet_3ed30289-b393-44f4-8e0b-55fdc09ffe3e" xlink:href="upst-20220630.xsd#upst_FairValueAndOtherAdjustmentsNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_InterestIncomeAndFairValueAdjustmentNet_962ad429-9d97-451d-b4bc-16ce428c7c5c" xlink:to="loc_upst_FairValueAndOtherAdjustmentsNet_3ed30289-b393-44f4-8e0b-55fdc09ffe3e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/FairValueMeasurementAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#FairValueMeasurementAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/FairValueMeasurementAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_e3bfd9e4-a21d-411d-a95d-744384e1af86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure_d056f6bc-9097-4b1c-a2e6-65bcff2e6c59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_e3bfd9e4-a21d-411d-a95d-744384e1af86" xlink:to="loc_us-gaap_LoansReceivableFairValueDisclosure_d056f6bc-9097-4b1c-a2e6-65bcff2e6c59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableFairValueDisclosure_9d84c9f3-807c-4187-b7a6-3b16a1b5c5be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_e3bfd9e4-a21d-411d-a95d-744384e1af86" xlink:to="loc_us-gaap_NotesReceivableFairValueDisclosure_9d84c9f3-807c-4187-b7a6-3b16a1b5c5be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServicingAssetAtFairValueAmount_af03dd43-fab1-40a8-a4d7-4e4d9a4e2a90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ServicingAssetAtFairValueAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_e3bfd9e4-a21d-411d-a95d-744384e1af86" xlink:to="loc_us-gaap_ServicingAssetAtFairValueAmount_af03dd43-fab1-40a8-a4d7-4e4d9a4e2a90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_0903e35a-7497-4fdf-9dac-74568ca6f3d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServicingLiabilityAtFairValueAmount_b242d03a-56e0-4f38-aaf3-f32084774194" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ServicingLiabilityAtFairValueAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_0903e35a-7497-4fdf-9dac-74568ca6f3d4" xlink:to="loc_us-gaap_ServicingLiabilityAtFairValueAmount_b242d03a-56e0-4f38-aaf3-f32084774194" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_TrailingFeeLiabilitiesFairValueDisclosure_939cb90d-9196-419d-bb55-677a4173f3fe" xlink:href="upst-20220630.xsd#upst_TrailingFeeLiabilitiesFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_0903e35a-7497-4fdf-9dac-74568ca6f3d4" xlink:to="loc_upst_TrailingFeeLiabilitiesFairValueDisclosure_939cb90d-9196-419d-bb55-677a4173f3fe" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/FairValueMeasurementLoansatFairValueDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#FairValueMeasurementLoansatFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/FairValueMeasurementLoansatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableNet_18d2f941-e4e8-4f16-b33e-45a0ff200c25" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_a494626b-c9c9-45eb-8762-f57141c58026" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_18d2f941-e4e8-4f16-b33e-45a0ff200c25" xlink:to="loc_us-gaap_NotesReceivableGross_a494626b-c9c9-45eb-8762-f57141c58026" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_49a0bda6-a8d1-4be5-83d1-c9bb4faa915a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_18d2f941-e4e8-4f16-b33e-45a0ff200c25" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_49a0bda6-a8d1-4be5-83d1-c9bb4faa915a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4b77646a-7500-4da4-bed6-e6af0da71057" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_136ce1f1-f235-4e21-83fe-5994dc530c70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4b77646a-7500-4da4-bed6-e6af0da71057" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_136ce1f1-f235-4e21-83fe-5994dc530c70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_efe53500-a98e-444f-a9b0-007c473b3ac7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4b77646a-7500-4da4-bed6-e6af0da71057" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_efe53500-a98e-444f-a9b0-007c473b3ac7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/GoodwillandIntangibleAssetsFutureExpectedAmortizationDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#GoodwillandIntangibleAssetsFutureExpectedAmortizationDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/GoodwillandIntangibleAssetsFutureExpectedAmortizationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_65cd2886-b5d5-4ee0-a22c-3ce8b7546fef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_c7d53b14-0352-4817-a2e9-6109fd25f963" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_65cd2886-b5d5-4ee0-a22c-3ce8b7546fef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_c7d53b14-0352-4817-a2e9-6109fd25f963" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_ee42dccf-4fff-437b-872c-20058896d08e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_65cd2886-b5d5-4ee0-a22c-3ce8b7546fef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_ee42dccf-4fff-437b-872c-20058896d08e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_160ceaa5-9203-43c9-8eb1-9f2c5df69276" xlink:href="upst-20220630.xsd#upst_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_65cd2886-b5d5-4ee0-a22c-3ce8b7546fef" xlink:to="loc_upst_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_160ceaa5-9203-43c9-8eb1-9f2c5df69276" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_6d0fff1a-14ff-43f4-82a0-09860396464f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_65cd2886-b5d5-4ee0-a22c-3ce8b7546fef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_6d0fff1a-14ff-43f4-82a0-09860396464f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_ae2aeb19-2270-49e4-8f18-4403466b4dec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_65cd2886-b5d5-4ee0-a22c-3ce8b7546fef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_ae2aeb19-2270-49e4-8f18-4403466b4dec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_bf1e9fa0-ec6e-44f1-a323-faf588bafeb8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_65cd2886-b5d5-4ee0-a22c-3ce8b7546fef" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_bf1e9fa0-ec6e-44f1-a323-faf588bafeb8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/BalanceSheetComponentsOtherAssetsDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#BalanceSheetComponentsOtherAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/BalanceSheetComponentsOtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_a5265429-fd16-4f40-af77-87fbd19c8e08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsMiscellaneous_bfa25112-d486-439e-8eba-f361f09b5107" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsMiscellaneous"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssets_a5265429-fd16-4f40-af77-87fbd19c8e08" xlink:to="loc_us-gaap_OtherAssetsMiscellaneous_bfa25112-d486-439e-8eba-f361f09b5107" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrentAndNoncurrent_33e0d3c1-d790-4bc1-be73-11e383b8cfa1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssets_a5265429-fd16-4f40-af77-87fbd19c8e08" xlink:to="loc_us-gaap_PrepaidExpenseCurrentAndNoncurrent_33e0d3c1-d790-4bc1-be73-11e383b8cfa1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssets_342d1596-87cf-4cdb-b22c-88527aef3da2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssets_a5265429-fd16-4f40-af77-87fbd19c8e08" xlink:to="loc_us-gaap_DepositsAssets_342d1596-87cf-4cdb-b22c-88527aef3da2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServicingAssetAtFairValueAmount_2670ada5-64a8-4356-8b18-4620c91ee85a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ServicingAssetAtFairValueAmount"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssets_a5265429-fd16-4f40-af77-87fbd19c8e08" xlink:to="loc_us-gaap_ServicingAssetAtFairValueAmount_2670ada5-64a8-4356-8b18-4620c91ee85a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivables_e6af3aea-9c46-4a68-bb0c-12aed4004781" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherReceivables"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssets_a5265429-fd16-4f40-af77-87fbd19c8e08" xlink:to="loc_us-gaap_OtherReceivables_e6af3aea-9c46-4a68-bb0c-12aed4004781" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedFeesAndOtherRevenueReceivable_d36047c1-6e03-45a4-ba27-9fbc3c8cf45c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedFeesAndOtherRevenueReceivable"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssets_a5265429-fd16-4f40-af77-87fbd19c8e08" xlink:to="loc_us-gaap_AccruedFeesAndOtherRevenueReceivable_d36047c1-6e03-45a4-ba27-9fbc3c8cf45c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#BalanceSheetComponentsPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_4b47b3d4-42ed-4b7c-90a5-79eb32df6fb8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_36d89044-31a1-483e-bb40-797205a42f4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_4b47b3d4-42ed-4b7c-90a5-79eb32df6fb8" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_36d89044-31a1-483e-bb40-797205a42f4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_c9daf280-0a9b-4edc-a3be-c564dc717f35" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_4b47b3d4-42ed-4b7c-90a5-79eb32df6fb8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_c9daf280-0a9b-4edc-a3be-c564dc717f35" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/BalanceSheetComponentsAccruedExpensesandOtherLiabilitiesDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#BalanceSheetComponentsAccruedExpensesandOtherLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/BalanceSheetComponentsAccruedExpensesandOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_6dc51427-3e5a-4deb-ac32-bd666f9c9282" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_9cab419d-85fc-4b90-8ffd-6c4c6a808081" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_6dc51427-3e5a-4deb-ac32-bd666f9c9282" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_9cab419d-85fc-4b90-8ffd-6c4c6a808081" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrentAndNoncurrent_abd3415d-ce1e-462e-a875-617d64739791" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_6dc51427-3e5a-4deb-ac32-bd666f9c9282" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrentAndNoncurrent_abd3415d-ce1e-462e-a875-617d64739791" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServicingLiabilityAtFairValueAmount_3fd63b48-98f4-483a-a5a8-24930e16f4c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ServicingLiabilityAtFairValueAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_6dc51427-3e5a-4deb-ac32-bd666f9c9282" xlink:to="loc_us-gaap_ServicingLiabilityAtFairValueAmount_3fd63b48-98f4-483a-a5a8-24930e16f4c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_TrailingFeeLiabilityAtFairValueAmount_49978dd1-15bc-44b9-b23b-5dff33d2c2d5" xlink:href="upst-20220630.xsd#upst_TrailingFeeLiabilityAtFairValueAmount"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_6dc51427-3e5a-4deb-ac32-bd666f9c9282" xlink:to="loc_upst_TrailingFeeLiabilityAtFairValueAmount_49978dd1-15bc-44b9-b23b-5dff33d2c2d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_d6dd2ef9-adfd-4c47-b3e6-9064daba64a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_6dc51427-3e5a-4deb-ac32-bd666f9c9282" xlink:to="loc_us-gaap_OtherLiabilities_d6dd2ef9-adfd-4c47-b3e6-9064daba64a7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/AcquisitionsConsiderationTransferredDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#AcquisitionsConsiderationTransferredDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/AcquisitionsConsiderationTransferredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_8255b1f0-c70f-4360-8cc8-87e877fa02ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_e30ab3e5-dd51-4e87-a38d-e9a95bac25ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_8255b1f0-c70f-4360-8cc8-87e877fa02ff" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_e30ab3e5-dd51-4e87-a38d-e9a95bac25ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_cecdbebc-4f48-43a3-bc05-477b9bc1bcdc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_8255b1f0-c70f-4360-8cc8-87e877fa02ff" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_cecdbebc-4f48-43a3-bc05-477b9bc1bcdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_BusinessCombinationConsiderationTransferredAssumedOptionsAttributableToPreCombinationServices_08234395-d19e-4790-a85a-5fc34dafb55d" xlink:href="upst-20220630.xsd#upst_BusinessCombinationConsiderationTransferredAssumedOptionsAttributableToPreCombinationServices"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_8255b1f0-c70f-4360-8cc8-87e877fa02ff" xlink:to="loc_upst_BusinessCombinationConsiderationTransferredAssumedOptionsAttributableToPreCombinationServices_08234395-d19e-4790-a85a-5fc34dafb55d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_BusinessCombinationConsiderationTransferredTransactionCostPaidOnBehalfOfAcquire_0a992007-175c-4848-a58b-f9c58e7b6c0c" xlink:href="upst-20220630.xsd#upst_BusinessCombinationConsiderationTransferredTransactionCostPaidOnBehalfOfAcquire"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_8255b1f0-c70f-4360-8cc8-87e877fa02ff" xlink:to="loc_upst_BusinessCombinationConsiderationTransferredTransactionCostPaidOnBehalfOfAcquire_0a992007-175c-4848-a58b-f9c58e7b6c0c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/AcquisitionsPurchasePriceAllocationDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#AcquisitionsPurchasePriceAllocationDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/AcquisitionsPurchasePriceAllocationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d3cff7e1-53d7-489d-9b02-512056ea41b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_cb08f9f7-fab1-466d-a837-e6995c28b87f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d3cff7e1-53d7-489d-9b02-512056ea41b5" xlink:to="loc_us-gaap_Goodwill_cb08f9f7-fab1-466d-a837-e6995c28b87f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_f5d76c29-2ed6-49c6-b157-635bb8afa463" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d3cff7e1-53d7-489d-9b02-512056ea41b5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_f5d76c29-2ed6-49c6-b157-635bb8afa463" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_1b07a949-5cdd-49e0-a398-ab1d3e65f910" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d3cff7e1-53d7-489d-9b02-512056ea41b5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_1b07a949-5cdd-49e0-a398-ab1d3e65f910" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_b81d48b8-51c1-47b7-be31-1d125308f5d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d3cff7e1-53d7-489d-9b02-512056ea41b5" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_b81d48b8-51c1-47b7-be31-1d125308f5d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsAcquiredLiabilitiesAssumedNet_cb42f225-7431-44b8-ada0-1fca88e02770" xlink:href="upst-20220630.xsd#upst_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsAcquiredLiabilitiesAssumedNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d3cff7e1-53d7-489d-9b02-512056ea41b5" xlink:to="loc_upst_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssetsAcquiredLiabilitiesAssumedNet_cb42f225-7431-44b8-ada0-1fca88e02770" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/BorrowingsSummaryDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#BorrowingsSummaryDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/BorrowingsSummaryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_8740d379-fe01-42fd-9b40-914bc1d96291" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LongTermAndShortTermDebtGross_2e2f3921-466c-43f4-aa13-c08fa7c63b44" xlink:href="upst-20220630.xsd#upst_LongTermAndShortTermDebtGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_8740d379-fe01-42fd-9b40-914bc1d96291" xlink:to="loc_upst_LongTermAndShortTermDebtGross_2e2f3921-466c-43f4-aa13-c08fa7c63b44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_2efd8e9c-a021-4fe0-92d2-77055a2681f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_8740d379-fe01-42fd-9b40-914bc1d96291" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_2efd8e9c-a021-4fe0-92d2-77055a2681f2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/BorrowingsMaturityDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#BorrowingsMaturityDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/BorrowingsMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_upst_LongTermAndShortTermDebtGross_b6124d3b-ad38-473f-9eab-65ac4b8939ff" xlink:href="upst-20220630.xsd#upst_LongTermAndShortTermDebtGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LongTermAndShortTermDebtMaturityYearTwo_b6a288e9-9d77-4e48-b779-9053126299ad" xlink:href="upst-20220630.xsd#upst_LongTermAndShortTermDebtMaturityYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_LongTermAndShortTermDebtGross_b6124d3b-ad38-473f-9eab-65ac4b8939ff" xlink:to="loc_upst_LongTermAndShortTermDebtMaturityYearTwo_b6a288e9-9d77-4e48-b779-9053126299ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LongTermAndShortTermDebtMaturityYearThree_58ac55e8-256f-4e49-9522-b443f04b3a9a" xlink:href="upst-20220630.xsd#upst_LongTermAndShortTermDebtMaturityYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_LongTermAndShortTermDebtGross_b6124d3b-ad38-473f-9eab-65ac4b8939ff" xlink:to="loc_upst_LongTermAndShortTermDebtMaturityYearThree_58ac55e8-256f-4e49-9522-b443f04b3a9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LongTermAndShortTermDebtMaturityYearOne_2315dea2-c1cd-4389-b2a4-abf51cd6feec" xlink:href="upst-20220630.xsd#upst_LongTermAndShortTermDebtMaturityYearOne"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_LongTermAndShortTermDebtGross_b6124d3b-ad38-473f-9eab-65ac4b8939ff" xlink:to="loc_upst_LongTermAndShortTermDebtMaturityYearOne_2315dea2-c1cd-4389-b2a4-abf51cd6feec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LongTermAndShortTermDebtMaturityYearFive_4e51d79d-4822-43d4-8a02-f86a4f514f88" xlink:href="upst-20220630.xsd#upst_LongTermAndShortTermDebtMaturityYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_LongTermAndShortTermDebtGross_b6124d3b-ad38-473f-9eab-65ac4b8939ff" xlink:to="loc_upst_LongTermAndShortTermDebtMaturityYearFive_4e51d79d-4822-43d4-8a02-f86a4f514f88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LongTermAndShortTermDebtMaturityYearFive_b5077fc7-eeb6-43b9-94d0-628d091d666a" xlink:href="upst-20220630.xsd#upst_LongTermAndShortTermDebtMaturityYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_LongTermAndShortTermDebtGross_b6124d3b-ad38-473f-9eab-65ac4b8939ff" xlink:to="loc_upst_LongTermAndShortTermDebtMaturityYearFive_b5077fc7-eeb6-43b9-94d0-628d091d666a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LongTermAndShortTermDebtMaturityYearFour_8a976476-b030-4930-b3e7-183f8c2de581" xlink:href="upst-20220630.xsd#upst_LongTermAndShortTermDebtMaturityYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_upst_LongTermAndShortTermDebtGross_b6124d3b-ad38-473f-9eab-65ac4b8939ff" xlink:to="loc_upst_LongTermAndShortTermDebtMaturityYearFour_8a976476-b030-4930-b3e7-183f8c2de581" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/LeasesLeaseLiabilityMaturityDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#LeasesLeaseLiabilityMaturityDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/LeasesLeaseLiabilityMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_1da4e051-92fe-4d79-87dd-f4dc8a715486" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_931a6887-681e-4fb1-88be-0c05c6d0eccd" xlink:href="upst-20220630.xsd#upst_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_1da4e051-92fe-4d79-87dd-f4dc8a715486" xlink:to="loc_upst_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_931a6887-681e-4fb1-88be-0c05c6d0eccd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_385f0cfa-2e82-47a3-9c75-1ecbfa235892" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_1da4e051-92fe-4d79-87dd-f4dc8a715486" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_385f0cfa-2e82-47a3-9c75-1ecbfa235892" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_c3d7fb19-ec4a-43f9-892b-325858738e93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_1da4e051-92fe-4d79-87dd-f4dc8a715486" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_c3d7fb19-ec4a-43f9-892b-325858738e93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_406c4344-5682-46b2-a469-f0b48966ef18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_1da4e051-92fe-4d79-87dd-f4dc8a715486" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_406c4344-5682-46b2-a469-f0b48966ef18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_5074aa1f-b1f0-45e9-8518-71132ebb5bf6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_1da4e051-92fe-4d79-87dd-f4dc8a715486" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_5074aa1f-b1f0-45e9-8518-71132ebb5bf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_7101b046-20bb-4f3f-965c-c3b007c1417a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_1da4e051-92fe-4d79-87dd-f4dc8a715486" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_7101b046-20bb-4f3f-965c-c3b007c1417a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/LeasesLeaseLiabilityMaturityDetails_1" xlink:type="simple" xlink:href="upst-20220630.xsd#LeasesLeaseLiabilityMaturityDetails_1"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/LeasesLeaseLiabilityMaturityDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_dd14d7fb-1faa-4089-86de-ed2407cb628d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_98e115b0-2250-4fbe-b953-144e8f4f0778" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_dd14d7fb-1faa-4089-86de-ed2407cb628d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_98e115b0-2250-4fbe-b953-144e8f4f0778" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_c0fd2171-242f-49cc-a315-622644193c86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_dd14d7fb-1faa-4089-86de-ed2407cb628d" xlink:to="loc_us-gaap_OperatingLeaseLiability_c0fd2171-242f-49cc-a315-622644193c86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_upst_LesseeOperatingLeaseLiabilityTenantImprovementReceivable_af4de5e4-758a-4ab4-97af-9f237389b506" xlink:href="upst-20220630.xsd#upst_LesseeOperatingLeaseLiabilityTenantImprovementReceivable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_dd14d7fb-1faa-4089-86de-ed2407cb628d" xlink:to="loc_upst_LesseeOperatingLeaseLiabilityTenantImprovementReceivable_af4de5e4-758a-4ab4-97af-9f237389b506" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.upstartholdings.com/role/NetIncomeLossPerShareCalculationDetails" xlink:type="simple" xlink:href="upst-20220630.xsd#NetIncomeLossPerShareCalculationDetails"/>
  <link:calculationLink xlink:role="http://www.upstartholdings.com/role/NetIncomeLossPerShareCalculationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_1192ab2a-66f3-433b-a391-c4da1c4d718e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_f573343c-3140-4693-b8e1-651a06f05ba0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_1192ab2a-66f3-433b-a391-c4da1c4d718e" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_f573343c-3140-4693-b8e1-651a06f05ba0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_94be3057-4b97-4310-abd1-90b464449db3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_1192ab2a-66f3-433b-a391-c4da1c4d718e" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_94be3057-4b97-4310-abd1-90b464449db3" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
